Table 2. Design of Computer Experiments.

We investigated 32 scenarios which are described in the table below. Each scenario is a combination of a procedure type (simple or complex), a per-pass adequacy rate (low or high), and a set of sampling protocols (one for ROSE and one for fixed sampling). Procedure types are categorized as simple (palpation guided) or as complex (image guided). Simple procedures have shorter setup times and require fewer resources than complex procedures. Variable definitions are provided in Appendix (S1 Text). Sampling protocols are defined by stopping rules (number of needle passes for fixed sampling, and number of adequate samples for ROSE). Please see the text for additional explanation of procedure types, adequacy rates and sampling protocols. In the simple procedure: t _setup = 4 min, c _var,o = $30/hr, c _var,c = $100/hr, c _np = $0/pass and c _pat = $20/hr. In the complex procedure: t _setup = 30 min, c _var,o = $260/hr, c _var,c = $100/hr, c _np = $30/pass and c _pat = $20/hr.

Procedure Type	Per-Pass Adequacy Rate	Sampling Protocol		Scenario
		ROSE, n R	No ROSE, n F
Simple	Low (p = 0.3)	1	1	2
			2	3
			3	4
			4	5
		2	5	2
			6	3
			7	4
			8	5
	High (p = 0.6)	1	9	2
			10	3
			11	4
			12	5
		2	13	2
			14	3
			15	4
			16	5
Complex	Low (p = 0.3)	1	17	2
			18	3
			19	4
			20	5
		2	21	2
			22	3
			23	4
			24	5
	High (p = 0.6)	1	25	2
			26	3
			27	4
			28	5
		2	29	2
			30	3
			31	4
			32	5