Table 3. Assumptions for Procedure Types.

Procedure types were categorized as simple (palpation guided) or as complex (image guided). Simple procedures have shorter setup times and require fewer resources than complex procedures. Variable definitions are provided in Appendix (S1 Text).Each cell shows the base value and the range used for sensitivity analysis. Cells that span both columns indicate values that are the same for both types of procedures. Please refer to the Methods and Glossary (S2 Text) for a more detailed description of procedure types.

Parameter		Parameter Value—Mean (range)
		Simple Procedure	Complex Procedure
Stopping point, ROSE	n R	1 adequate sample (1, 2)
Stopping point, fixed	n F	3 needle passes (2–5)
Sensitivity of cytologist	sn	0.95 (0.90–1.00)
Specificity of cytologist	sp	0.975 (0.95–1.00)
Per-pass adequacy rate	p	Low: 0.3 (0.2–0.4) High: 0.6 (0.5–0.7)
Time per needle pass, fixed	$t_{pass}^F$	2 min (1–3)
Time per needle pass, ROSE	$t_{pass}^R$	9 min (6–12)
Setup time	t setup	4 min (3–5)	30 min (20–30)
Variable cost, other	c var,o	$30/ hr (20–40)	$260/ hr (190–330)
Variable cost, cytologist	c var,c	$100/hr (75–125)	$100/hr (75–125)
Total variable cost, fixed	$c_{var}^F$	$130/hr (20–40)	$260/hr (190–330)
Total variable cost, ROSE	$c_{var}^R$	$130/hr (95–165)	$360/hr (290–440)
Cost per needle pass	${\overline{c}}_{np}$	$0/pass	$30/pass (15–45)
Fixed cost per procedure	c fixed	$150(100–200)	$300 (150–450)
Cost to patient	c pat	$20/hr (15–25)