Table 4.
Within disease course MRI comparisons between subjects with and without migraine.
| RRMS (n = 320) |
SPMS (n = 124) |
PPMS (n = 36) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| W/o migraine (n = 241) |
Migraine (n = 79) | p-Value | W/o migraine (n = 104) | Migraine (n = 20) | p-Value | W/o migraine (n=30) | Migraine (n = 6) | p-Value | |
| Presence of CE lesions | 68 (28.2) | 33 (41.8) | 0.035 | 26 (25) | 7 (35) | 0.354 | 0 (0) | 0 (0) | NA |
| Number of CE lesions | 0.3 (0.84) | 1.19 (4.9) | 0.023 | 0.07 (.3) | 0 (0) | 0.224 | 0 (0) | 0 (0) | 0.806 |
| CE-LV | 41.1 (144.4) | 164.4 (651.9) | 0.02 | 6.1 (28.6) | 0 (0) | 0.324 | 1.6 (8.5) | 0 (0) | 0.806 |
| Number of T2 lesions | 27.1 (19.3) | 28.2 (17.9) | 0.951 | 33.8 (19.7) | 29.4 (24.1) | 0.241 | 31.8 (24.4) | 15.3 (11.7) | 0.081 |
| T2-LV | 11,421.3 (14,030.7) | 12,163.3 (14,300) | 0.732 | 19,357.2 (17,541.4) | 19,850.3 (20,378.2) | 0.701 | 17,256.3 (19,859.5) | 10,457.4 (12,508.5) | 0.413 |
| Number of T1 lesions | 10.1 (10.8) | 9.7 (11.9) | 0.638 | 15.1 (12.3) | 12.4 (14.1) | 0.352 | 11.6 (12.7) | 11.3 (10.4) | 0.98 |
| T1-LV | 2424.2 (4769.6) | 3020.2 (8106.5) | 0.417 | 5050.6 (7378.7) | 4338.9 (6419.1) | 0.580 | 2236.3 (2554.0) | 2015.9 (2725.2) | 0.850 |
| NBV | 1492.8 (88.5) | 1488.8 (96.5) | 0.187 | 1414.7 (77.4) | 1428.5 (70.7) | 0.832 | 1430.9 (93.9) | 1485.9 (60.8) | 0.688 |
| NGMV | 742.5 (66.3) | 748.9 (64.7) | 0.747 | 697.5 (58.9) | 710 (54.5) | 0.59 | 715.7 (48.4) | 732.3 (57.5) | 0.521 |
| NWMV | 750.3 (60.9) | 740 (67.2) | 0.144 | 717.2 (71.6) | 718.6 (61.2) | 0.825 | 715.3 (71.3) | 753.6 (76.2) | 0.423 |
| NLVV | 45.8 (20.1) | 45.6 (22.8) | 0.402 | 60.3 (22.7) | 54.2 (23.6) | 0.353 | 57 (26.8) | 43 (8.8) | 0.494 |
| NCV | 600.1 (55.5) | 609.8 (52.7) | 0.822 | 564.6 (50.9) | 570 (41.8) | 0.903 | 580.4 (41.9) | 593.4 (55.3) | 0.619 |
MS—multiple sclerosis; RRMS—relapsing–remitting; SPMS—secondary-progressive; PPMS—primary-progressive; SD—standard deviation; CE—contrast enhancing; LV—lesion volume; NA—not available; NBV—normalized brain volume; NGMV—normalized gray matter volume; NWMV—normalized white matter volume; NLVV—normalized lateral ventricular volume; NCV—normalized neocortical volume.
All data are presented as mean and standard deviations. The presence of CE is reported as the number and percentage. Volumetric calculations are presented in cubic millimeters (mm3) for LV and in cubic centimeters (cm3) for brain volumes.
The comparison between RRMS, SPMS and PPMS groups was performed using analysis of covariance with age, gender and disease-modifying treatment, as covariates. p-Values < 0.05 were considered significant (highlighted in bold) after correction for multiple comparisons.