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. 2015 Aug 28;10(8):e0136994. doi: 10.1371/journal.pone.0136994

Fig 1. The Transcriptional Profile Related to Chronic Kidney Disease (CKD).

Fig 1

(A) Distribution of differences in gene expression between control kidney RNA (Control) and RNA extracted from 48 CKD biopsies. Microarray analysis was performed and genes down-regulated (z-score < -2.0, green) or up-regulated (z-score > 2.0, blue) in CKD are indicated. (B) Biological functions of the genes showing differential expression in CKD samples were classified according to their Gene Ontology and P values were calculated with MetaCore software. (C) Relationship between P values from Kruskal-Wallis test on tubulointerstitial fibrosis and tubular cell damage. Each symbol represents one gene. Gray or black circles indicate genes with any P values < 0.05; open circles represent genes with both P values > 0.05. HAVCR1, hepatitis A virus cellular receptor 1; LCN2, lipocalin 2; SOX9, SRY-box 9; WFDC2, WAP four-disulfide core domain 2; NKX6-2, NK6 homeobox 2.