Table 2. Association of mTOR rs1064261 and AKT rs1130233 polymorphisms with the risk of atrophic gastritis and gastric cancer.
| Stratified | SNP | Gastric mucosa status | AG vs. CON | GC vs. AG | GC vs. CON | GC vs. CON+AG | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CON(%) | AG(%) | GC(%) | OR(95%CI) | P-value | OR(95%CI) | P-value | OR(95%CI) | P-value | OR(95%CI) | P-value | ||
| mTOR rs1064261* | ||||||||||||
| TT | 560(83.2) | 584(85.1) | 402(83.2) | 1(Ref) | 1(Ref) | 1(Ref) | 1(Ref) | |||||
| TC | 107(15.9) | 97(14.1) | 76(15.7) | 0.92(0.66–1.28) | 0.626 | 1.22(0.87–1.71) | 0.259 | 0.96(0.67–1.37) | 0.804 | 1.12(0.83–1.51) | 0.478 | |
| CC | 6(0.9) | 5(0.7) | 5(1.0) | 0.56(0.15–2.09) | 0.391 | 1.78(0.50–6.36) | 0.374 | 1.26(0.35–4.51) | 0.722 | 1.38(0.46–4.15) | 0.564 | |
| HWE | 0.724 | |||||||||||
| AKT rs1130233* | ||||||||||||
| GG | 144(21.5) | 129(19.1) | 89(18.5) | 1(Ref) | 1(Ref) | 1(Ref) | 1(Ref) | |||||
| GA | 329(49.0) | 362(53.5) | 236(49.0) | 1.21(0.89–1.64) | 0.234 | 1.06(0.76–1.49) | 0.719 | 1.14(0.80–1.62) | 0.481 | 1.16(0.86–1.56) | 0.347 | |
| AA | 198(29.5) | 186(27.5) | 157(32.6) | 1.09(0.77–1.54) | 0.637 | 1.26(0.88–1.82) | 0.214 | 1.25(0.85–1.85) | 0.252 | 1.31(0.95–1.82) | 0.100 | |
| HWE | 0.737 | |||||||||||
| Sex | mTOR rs1064261 § | |||||||||||
| Male | TT | 283(82.7) | 336(87.0) | 260(82.3) | 1(Ref) | 1(Ref) | 1(Ref) | 1(Ref) | ||||
| TC | 55(16.1) | 48(12.4) | 54(17.1) | 0.70(0.44–1.12) | 0.138 | 1.55(1.00–2.38) | 0.049 | 0.97(0.62–1.51) | 0.880 | 1.29(0.89-.186) | 0.184 | |
| CC | 4(1.2) | 2(0.5) | 2(0.6) | 0.28(0.04–1.94) | 0.199 | 1.34(0.18–9.79) | 0.775 | 0.73(0.12–4.30) | 0.724 | 0.87(0.17–0.448) | 0.863 | |
| Sex | AKT rs1130233 § | |||||||||||
| Male | GG | 74(21.7) | 84(22.0) | 53(16.8) | 1(Ref) | 1(Ref) | 1(Ref) | 1(Ref) | ||||
| GA | 170(49.9) | 200(52.5) | 154(48.7) | 0.97(0.64–1.47) | 0.891 | 1.32(0.87–2.00) | 0.192 | 1.30(0.83–2.05) | 0.255 | 1.33(0.91–1.94) | 0.139 | |
| AA | 97(28.4) | 97(25.5) | 109(34.5) | 0.88(0.55–1.42) | 0.609 | 1.76(1.12–2.77) | 0.014 | 1.70(1.03–2.81) | 0.039 | 1.71(1.14–2.57) | 0.009 | |
| H.pylori | AKT rs1130233 # | |||||||||||
| Negative | GG | 118(22.6) | 43(15.9) | 47(20.6) | 1(Ref) | 1(Ref) | 1(Ref) | 1(Ref) | ||||
| GA | 246(47.2) | 149(55.2) | 105(46.1) | 1.69(1.12–2.54) | 0.012 | 0.72(0.43–1.19) | 0.194 | 1.21(0.78–1.87) | 0.400 | 1.02(0.67–1.53) | 0.945 | |
| AA | 157(30.1) | 78(28.9) | 76(33.3) | 1.39(0.89–2.18) | 0.144 | 0.94(0.55–1.62) | 0.830 | 1.29(0.81–2.05) | 0.288 | 1.18(0.76–1.83) | 0.470 | |
Note:
*using Logistic Regession adjusted by sex, age and H.pylori infection status.
§using Logistic Regession adjusted by age and H.pylori infection status.
#using Logistic Regession adjusted by sex and age.
Abbreviations: SNP, single nucleotide polymorphism; CON, control; AG, atrophic gastritis; GC, gastric cancer; OR, odds ratio; CI, confidence interval; Ref, reference; HWE, Hardy-Weinberg Equilibrium in population.