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. 2015 Aug 28;10(8):e0136538. doi: 10.1371/journal.pone.0136538

Fig 1. C/EBPβ-/- mice exhibit increased susceptibility to systemic candidiasis but are resistant to oral candidiasis.

Fig 1

(A) The indicated mice (n = 3 per group) were injected with C. albicans in the lateral tail vein. Time to sacrifice is indicated (days). *P<0.05 versus (vs) C/EBPβ+/- mice using Log-rank (Mantel-Cox). (B) The indicated mice were infected sublingually with C. albicans for 75 mins. After 5 d, fungal loads in tongue were assessed by CFU enumeration of tongue tissue homogenates. Bars indicate geometric mean with 95% CI. C/EBPβ+/+ SHAM (n = 3), C/EBPβ+/+ (n = 5), C/EBPβ+/- (n = 9), C/EBPβ-/- (n = 3), C/EBPβ+/+ plus 225mg/kg cortisone (n = 3); cortisone acetate was administered by subcutaneous injection on days -1, +1 and +2 relative to infection. P<0.05 by t-test with Mann-Whitney correction: * vs C/EBPβ+/+ WT, ≠ vs C/EBPβ+/-, # vs C/EBPβ-/-, π vs C/EBPβ+/+ 225mg/kg. C. Weights of mice were assessed daily and graphed as percent of starting weight. * vs C/EBPβ+/+ WT. P<0.05 by t-test with Mann-Whitney correction. Experiment was performed once.