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. 2015 Apr 8;74(9):1778–1782. doi: 10.1136/annrheumdis-2014-206752

Figure 3.

Figure 3

The ZIP group of zinc transporter genes are upregulated in the inflammation-associated subgroup of osteoarthritic (OA) hip patients. Gene expression was measured in five neck of femur (NOF), five OA hip cluster 1 and six OA hip cluster 2 patients. Data are presented as 2−ΔΔCt with the NOF data serving as the control group and are shown as the mean and the standard error of the mean. Statistical analysis was performed by one-way analysis of variance with the Tukey test. ***p<0.001, **p<0.01, *p<0.05. (A) Analysis of IL1B expression. (B) Analysis of the ZIP group of zinc transporter genes. (C) Gene expression analysis of the zinc transporter gene regulator MTF1. Gene expression analysis of the MTF1 targets (D) MMP13 and (E) ADAMTS5. Gene expression analysis of the metallothioneins (F) MT1A; (G) MT1G and (H) MT1H. (I) Gene expression analysis of the ZnT group of zinc transporter genes.