Figure 1. Brain parenchymal, gray matter, and white matter volumes in tertiles of serum NT-proBNP.

Bars represent mean values (standard error) of total brain parenchymal volume, gray matter volume, and white matter volume adjusted for age and sex, intracranial volume, education, current smoking, hypertension, diabetes mellitus, systolic blood pressure, history of coronary heart disease, history of stroke, total cholesterol, body mass index, atrial fibrillation, and glomerular filtration rate. The p values were calculated using the continuous value of log-transformed NT-proBNP. *Significant difference between low and high tertiles. **Significant difference between middle and high tertiles. NT-proBNP = N-terminal fragment of the prohormone brain natriuretic peptide.