Table 1.
Signal | P-TEFb recruiting factors | References |
---|---|---|
Environmental signals | ||
Heat shock | HSF | [58] |
Hypoxia | HIF1α CDK8-containing mediator |
[53] |
Serum stimulation | BRD4 CDK8-containing mediator |
[52], [60] |
Proinflammation signals | ||
LPS, TNFα | NF-κB BRD4 |
[62–63] |
Hormones | ||
Estrogen, testosterone, retinoic acid | ERα, AR, RAR | [65–67] |
Lineage differentiation signals | ||
Hematopoiesis | LDB1 complexes TIF1γ GATA-1 Ikaros |
[76–82] |
ESC differentiation | c-Myc SEC KLF4 |
[10],[71],[85] |
Disease signals | ||
MLL-fusion leukemia | SECs BRD4 |
[89–90] |
HIV infection | TAT SEC |
[91–96] |
Cardiac hypertrophy | GATA4 BRD4 |
[97–102] |