TABLE 3.

Subgroup analysis to identify any impact of the type of ischemic heart disease, location of myocardial infarction, left ventricular ejection fraction at baseline, route of bone marrow cell transplantation, and methods of cell preparation on outcome variables.

Outcome	Difference in mean (95% CI)	BMC therapy (n)	Control (n)	Difference in mean (95% CI)	BMC therapy (n)	Control (n)	P value for Interaction
	Acute MI			Chronic IHD
LVEF	2.49 (1.19, 3.79)	1065	832	3.84 (2.30, 5.38)	361	248	0.19
Infarct scar size	−2.13 (−3.49, −0.78)	668	545	−5.90 (−8.03, −3.78)	56	25	0.003
LVESV	−4.87 (−7.29, −2.45)	713	567	−10.37 (−18.56, −2.18)	222	144	0.21
LVEDV	−2.55 (−5.00, −0.10)	718	572	−1.84 (−9.13, 5.46)	201	129	0.86
	Anterior Wall MI			MI in Other Territories
LVEF	2.04 (0.18, 3.89)	497	373	3.13 (1.79, 4.47)	833	644	0.35
Infarct scar size	−1.90 (−3.72, −0.07)	311	258	−3.04 (−5.70, −0.38)	369	280	0.49
LVESV	−5.57 (−9.34, −1.81)	294	225	−7.34 (−12.52, −2.16)	516	390	0.59
LVEDV	−9.57 (−16.50, −2.63)	272	218	−1.48 (−3.04, 0.08)	518	397	0.03
	Baseline LVEF <41 %			Baseline LVEF ≥41%
LVEF	2.85 (1.34, 4.35)	602	454	2.97 (1.63, 4.31)	824	626	0.90
Infarct scar size	−2.16 (−3.97, −0.34)	265	217	−2.38 (−4.76, 0.00)	449	343	0.88
LVESV	−9.42 (−14.53, −4.32)	369	287	−4.70 (−7.40, −1.99)	566	424	0.11
LVEDV	−3.79 (−7.60, 0.02)	348	272	−1.60 (−6.12, 2.91)	571	429	0.47
	Baseline LVEF <50 %			Baseline LVEF ≥50 %
LVEF	3.03 (1.94, 4.11)	1240	910	2.77 (0.86, 4.69)	206	170	0.82
Infarct scar size	−2.84 (−4.24, −1.45)	832	702	−0.72 (−3.63, 2.19)	84	67	0.20
LVESV	−7.24 (−10.31, −4.17)	770	565	−3.43 (−7.69, 0.84)	165	146	0.15
LVEDV	−4.38 (−7.88, −0.87)	777	578	1.66 (−4.02, 7.34)	165	146	0.08
	IC - CIHD			IM - CIHD
LVEF	2.37 (0.38, 4.37)	199	151	4.12 (2.33, 5.92)	238	164	0.20
Infarct scar size	−3.02 (−7.67, 1.64)	70	48	−5.90 (−16.36, 4.56)	80	55	0.62
LVESV	−4.86 (−11.15, 1.44)	74	43	−11.95 (−23.04, −0.86)	202	136	0.28
LVEDV	1.61 (−5.12, 8.34)	74	43	−5.37 (−17.71, 6.98)	127	93	0.33
	Other Ficoll-based methods			Lymphoprep
LVEF	2.93 (1.66, 4.20)	1167	894	2.31 (−0.08, 4.69)	148	137	0.65
Infarct scar size	−1.47 (−3.37, 0.42)	389	300	−1.67 (−4.56, 1.22)	136	126	0.91
LVESV	−6.45 (−9.91, −2.99)	641	504	−6.46 (−8.88, −4.05)	69	62	1.00
LVEDV	−4.21 (−7.97, −0.45)	641	504	−9.54 (−27.93, 8.85)	69	62	0.58
	No Heparin			Heparinized saline
LVEF	1.75 (0.54, 2.96)	680	431	5.15 (3.17, 7.12)	347	321	0.004
Infarct scar size	−0.49 (−2.74, 1.75)	275	165	−3.89 (−5.96, −1.82)	202	190	0.03
LVESV	−3.74 (−6.30, −1.18)	429	295	−7.62 (−12.20, −3.04)	260	233	0.15
LVEDV	−4.40 (−9.94, 1.14)	413	285	−1.87 (−3.95, 0.22)	260	233	0.40

Abbreviations: CIHD, chronic ischemic heart disease; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume; IC, intracoronary; IM, intramuscular; MI, myocardial infarction; BM, Bone marrow