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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Thromb Res. 2015 May 28;136(3):493–503. doi: 10.1016/j.thromres.2015.05.027

Fig. 2. EP receptors and signaling pathways.

Fig. 2

PGE2 binds to four receptor subtypes: EP1, EP2, EP3, and EP4. Each receptor has distinct signaling pathways depending on the cell type in which it is expressed. All major mediators and second messengers are shown for each receptor subtype. The details of these pathways continue to be refined.