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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Thromb Res. 2015 May 28;136(3):493–503. doi: 10.1016/j.thromres.2015.05.027

Fig. 3. Representative traces of the two phenotypic groups analyzed by light transmission aggregometry.

Fig. 3

Healthy volunteers or patients undergoing PCI were consented following a protocol approved by the Vanderbilt Institutional Review Board. Platelet rich plasma (PRP) was obtained from citrated blood, and platelet count was adjusted to 250,000 cells per μl with autologous platelet poor plasma (PPP). PRP was preincubated with PGE2 100 nmol/L (PGE2) or vehicle (control) for 30 s, followed by a sub-maximal concentration of U46,619. Aggregation was recorded for 6 min as described by Smith et al [56]. The frequency of each phenotypic group is indicated (n=104).