Table 3.

Measures of association for comparison of ART conceived children to non-ART conceived children for diagnosis age outcomes

Outcome and birth year	Total population no adjustment	Restriction sample + adjustment for socio-demographic factorsa	Restriction, singleton sample + adjustment for socio-demographic factors	Restriction, singleton sample + adjustment for socio-demographic and causal path factors
Mean age autism dx (year)	Mean difference (log-transformed)	Mean difference (log-transformed)	Mean difference (log-transformed)	Mean difference (log-transformed)
1997–1999	−0.13*	−0.08	−0.06	−0.10
2000–2002	−0.10*	−0.04	−0.07	−0.07
2003–2004	−0.10*	−0.07*	−0.03	−0.001
2005–2006	−0.02	0.01	0.04	0.04
All birth years	−0.10*	−0.06*	−0.04	−0.05
Diagnosis at <4 years of age	OR (95 % CI)	OR (95 % CI)	OR (95 % CI)	OR (95 % CI)
1997–1999	1.8 (1.3–2.7)	1.4 (0.94–2.1)	1.3 (0.7–2.4)	1.4 (0.7–2.8)
2000–2002	1.8 (1.3–2.5)	1.4 (0.95–1.9)	1.7 (0.9–3.0)	1.6 (0.9–3.1)
2003–2004	2.3 (1.5–3.5)	1.7 (1.1–2.7)	1.2 (0.6–2.3)	0.9 (0.4–1.9)
2005–2006	1.1 (0.8–1.6)	0.9 (0.6–1.3)	0.8 (0.5–1.5)	0.9 (0.5–1.6)
All birth years	1.8 (1.5–2.1)	1.4 (1.1–1.7)	1.3 (0.9–1.7)	1.3 (0.9–1.8)

The sample restricted for socio-demographic comparability excludes children whose mothers were less than 20 years of age at the time of their birth, had less than a high school diploma, had prenatal care or delivery paid for by Medi-Cal or other public source, or had missing information on prenatal care, inadequate prenatal care or started prenatal care in the third trimester. The sample further restricted to singletons excludes all of the aforementioned children and additionally excludes all children born in twin or higher-order multiple birth deliveries

Statistically significant values are given in bold

* p < 0.05

^aAll adjusted models included child sex, maternal age at child’s birth, maternal educational level at child’s birth, maternal race-ethnicity and immigration status as potential confounders. The final model additionally included PTB and SGA