Table 2.
Cases of IPD and pneumococcal pneumonia and matched controls. PCVs effectiveness (95% CIs) in Puglia, 2006–2012.
| Vaccination status | IPD cases (N = 9) | Matched controls (N = 27) | OR (95% CI) | p ∗ | VE (95% CI) | ||
|---|---|---|---|---|---|---|---|
| N | % | N | % | ||||
| Fully vaccinated# | 8 | 88.89 | 26 | 96.30 | 0.31 (0.12–0.7) | 0.003 | 69% (30%–88%) |
| Incompletely vaccinated## | 1 | 11.11 | 0 | 0 | n.c.∗∗ | 0.31 | |
| Not vaccinated | 0 | 0 | 1 | 3.70 | Ref. | Ref. | |
|
| |||||||
| Vaccination status | Pneumococcal pneumonia cases | Matched controls | OR (95% CI) | p ∗ | VE (95% CI) | ||
| (N = 30) | (N = 90) | ||||||
| N | % | N | % | ||||
|
| |||||||
| Fully vaccinated# | 19 | 63.33 | 81 | 90.00 | 0.23 (0.13–0.39) | <0.001 | 77% (61%–87%) |
| Incompletely vaccinated## | 11 | 36.67 | 7 | 7.78 | 1.57 (0.56–4.78) | >0.05 | |
| Not vaccinated | 0 | 0 | 2 | 2.22 | Ref. | Ref. | |
|
| |||||||
| Vaccination status | Total cases (N = 39) | Matched controls (N = 117) | OR (95% CI) | p ∗ | VE (95% CI) | ||
| N | % | N | % | ||||
|
| |||||||
| Fully vaccinated# | 27 | 69.23 | 107 | 91.46 | 0.25 (0.16–0.39)∗∗∗ | <0.001 | 75% (61%–84%) |
| Incompletely vaccinated## | 12 | 30.77 | 7 | 5.98 | 1.71 (0.62–5.13) | >0.05 | |
| Not vaccinated | 0 | 0 | 3 | 2.56 | Ref. | Ref. | |
# Fully vaccinated cases: children vaccinated with ≥3 doses of PCV7/PCV13 at least one month before the date of hospitalization; fully vaccinated control: presumed healthy children vaccinated with ≥3 doses.
## Incompletely vaccinated cases: children vaccinated with <3 doses of PCV7/PCV13 at least one month before the date of hospitalization; incompletely vaccinated control: presumed healthy children vaccinated with <3 doses.
∗Exact McNemar significance probability. ∗∗n.c.: not calculable. ∗∗∗ Power of estimation: 84.6%.