Table 2.

AUC estimates calculated in ROC analyses and ROC characteristics at optimal cut-offs.

	AUC (95% CI)	p value	Cut-off	Sensitivity (95% CI)	Specificity (95% CI)	PPV	NPV
ACE-R
PD-NC versus PD-MCI	0.78 (0.66–0.90)	<0.001	88.5	0.68 (0.50–0.81)	0.91 (0.69–0.98)	0.93	0.63
PD-MCI versus PD-D	0.78 (0.63–0.93)	0.007	82.5	0.70 (0.35–0.92)	0.73 (0.56–0.86)	0.41	0.90
ACE-R AO
PD-NC versus PD-MCI	0.64 (0.50–0.78)	0.077	17.5	0.51 (0.35–0.68)	0.73 (0.50–0.88)	0.76	0.47
PD-MCI versus PD-D	0.92 (0.77–1.00)	<0.001	15.5	0.90 (0.54–0.99)	0.97 (0.84–1.00)	0.90	0.97
ACE-R M
PD-NC versus PD-MCI	0.68 (0.55–0.82)	0.020	22.5	0.76 (0.58–0.88)	0.50 (0.29–0.71)	0.72	0.55
PD-MCI versus PD-D	0.71 (0.54–0.88)	0.043	20.5	0.90 (0.54–0.99)	0.46 (0.30–0.63)	0.31	0.94
ACE-R F
PD-NC versus PD-MCI	0.75 (0.61–0.88)	0.002	11.5	0.70 (0.53–0.84)	0.73 (0.50–0.88)	0.81	0.59
PD-MCI versus PD-D	0.62 (0.42–0.82)	0.264	8.5	0.50 (0.20–0.80)	0.76 (0.58–0.88)	0.36	0.85
ACE-R L
PD-NC versus PD-MCI	0.62 (0.47–0.76)	0.141	24.5	0.35 (0.21–0.53)	0.91 (0.69–0.98)	0.87	0.45
PD-MCI versus PD-D	0.56 (0.34–0.77)	0.585	23.5	0.40 (0.14–0.73)	0.84 (0.67–0.93)	0.40	0.84
ACE-R VA
PD-NC versus PD-MCI	0.63 (0.48–0.77)	0.110	15.5	0.62 (0.45–0.77)	0.64 (0.41–0.82)	0.74	0.50
PD-MCI versus PD-D	0.75 (0.58–0.93)	0.015	14.5	0.60 (0.27–0.86)	0.78 (0.61–0.90)	0.43	0.88

ACE-R: Addenbrooke's Cognitive Examination, global score.

PD-NC: subjects with Parkinson's disease with normal control.

PD-MCI: subjects with Parkinson's disease with mild cognitive impairment.

PD-D: subjects with Parkinson's disease with dementia.

ACE-R AO: Addenbrooke's Cognitive Examination, domain attention and orientation.

ACE-R M: Addenbrooke's Cognitive Examination, domain memory.

ACE-R F: Addenbrooke's Cognitive Examination, domain verbal fluency.

ACE-R L: Addenbrooke's Cognitive Examination, domain language.

ACE-R VA: Addenbrooke's Cognitive Examination, domain visual spatial abilities.