Fig. 3. The effect of dexmedetomidine on CPA-induced [Ca²⁺]_i release and Ca²⁺ entry. The CPA-induced [Ca²⁺]_i increase in the presence of 2 mM extracellular Ca²⁺ in the absence (A) or presence (B) of 100 ng/mL dexmedetomidine. (C) Analysis of CPA-induced Ca²⁺ release and influx as determined using R_340/380 fluorescence ratios. The upper bars indicate the extracellular solutions applied to the cells. Three separate experiments were performed and each point represents a mean±SEM.