Fig. 3. Effects of SQ-22536 and cell-permeable 8-bromo-cyclic AMP (8-bromo-cAMP) on pacemaker potentials in cultured interstitial cells of Cajal (ICC) from mouse colon. (A) Treatment with SQ-22536 (100 µM) showed inhibitory effects on pacemaker potentials. (B) Treatment with 8-bromo-cAMP (100 µM) increased the frequency of pacemaker potentials in colonic ICC. Vertical solid lines show the amplitude of pacemaker potentials and horizontal solid lines show the duration of recording (s) of pacemaker potentials.
