Fig. 6. Effects of forskolin on pacemaker potentials in cultured interstitial cells of Cajal (ICC) from mouse colon. (A) Treatment with forskolin (50 nM) had an inhibitory effect on pacemaker potentials, similar to that of pituitary adenylate cyclase-activating peptide (PACAP). (B) Co-treatment with glibenclamde (10 µM) inhibited forsklin-induced action on colonic ICC. (C) and (D) summarize the effects of forskolin on pacemaker potentials in colonic ICC with glibenclamide. Bars represent the means±SE. *Asterisks indicate a statistically significantly difference from controls (p<0.05). Con, control.
