Fig. 7. Effects of NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one (ODQ) on pituitary adenylate cyclase-activating peptide (PACAP)-induced responses of pacemaker potentials in cultured interstitial cells of Cajal (ICC) from mouse colon. (A) L-NAME (a competitive inhibitor of NO synthase; 10 µM) did not have any effect on PACAP-induced action in colonic ICC. (B) ODQ (an inhibitor of guanylate cyclase; 10 µM) also did not show any effect on PACAP-induced action in colonic ICC. (C) and (D) summarize the effects of PACAP on pacemaker potentials in colonic ICC with L-NAME or ODQ. Bars represent the means±SE. Con, control.
