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. 2015 Aug 10;112(34):E4726–E4734. doi: 10.1073/pnas.1514105112

Fig. S2.

Fig. S2.

Total mRNA levels of SR proteins and hnRNP splicing factors were comparable in WT and mutSRSF2 CRISPR clones. (Upper) Total mRNA levels of SRSF2 and 11 other SR proteins in K562 parental cells and WT and mutSRSF2 CRISPR cells. (Lower) Total mRNA levels of 16 major hnRNP splicing factors. Except that there were small but significant differences for HNRNPA2B1 (∼7% decrease in mutant vs. WT SRSF2 cells, P = 0.043) and HNRNPC (∼19% decrease, P = 0.008), the mRNA levels of the other 14 hnRNP splicing factors and all 12 SR proteins did not show significant changes between WT and mutant SRSF2 cells. Note that expression of SRSF8 and SRSF12 was barely detectable.