Table S2.
IL1RAP-immunostaining of normal tissues
| Tissue | Anti-IL1RAP mAb3F8 mIgG1 | mIgG1 isotype control |
| Adrenal 1 | 1+ diffuse in stromal parts | 0 |
| Adrenal 2 | 1+ diffuse in stromal parts | 0 |
| Adrenal 3 | 1+ diffuse in stromal parts | 0 |
| BM 1 | 2–3+ in undefined cells | 1–2+ in undefined cells |
| BM 2 | 2–3+ in undefined cells | 1–2+ in undefined cells |
| BM 3 | 2–3+ in undefined cells | 1–2+ in undefined cells |
| Breast, 1 | 0 | Local in mucin |
| Breast, 2 | 0 | 0 |
| Breast, 3 | 0 | Local in mucin |
| Brain, cerebellum, 1 | 0 | 0 |
| Brain, cerebellum, 2 | 0 | 0 |
| Brain, cerebellum, 3 | 0 | 0 |
| Brain, cortex, 1 | 0 | 0 |
| Brain, cortex, 2 | 0 | 0 |
| Brain, cortex, 3 | 0 | 0 |
| Brain, pituitary, 1 | 0 | 0 |
| Brain, pituitary, 2 | 0 | 0 |
| Brain, pituitary, 3 | 0 | 0 |
| Colon, 1 | 0 | 0 |
| Colon, 2 | 2+ diffuse in lamina propria and epithelial cells | 1–2+ diffuse in lamina propria and epithelial cells |
| Colon, 3 | 0 | 0 |
| Aorta,1 | 0 | 0 |
| Aorta,2 | 0 | 0 |
| Aorta,3 | 0 | Some unspecific at edge of section |
| Esophagus, 1 | 1+ in epithelial cells | 0 |
| Esophagus, 2 | 1+ in epithelial cells | 0 |
| Esophagus, 3 | 1+ in epithelial cells | 0 |
| Fallopian tube, 1 | 0 | 0 |
| Fallopian tube, 2 | 1+ diffuse local | 1+ diffuse local |
| Fallopian tube, 3 | 1+ diffuse local and some endogenous peroxidase | 1+ diffuse local and some endogenous peroxidase |
| Heart, 1 | 0 | 0 |
| Heart, 2 | 0 | 0 |
| Heart, 3 | 0 | 0 |
| Kidney, 1 | 0 | 0 |
| Kidney, 2 | 0 | 0 |
| Kidney, 3 | 0 | 0 |
| Liver, 1 | 1+ diffuse | Some very weak diffuse |
| Liver, 2 | 1+ diffuse | Some very weak diffuse |
| Liver, 3 | 1+ diffuse | Some very weak diffuse |
| Lung, 1 | 2–3+ in undefined cells | 2–3+ in undefined cells |
| Lung, 2 | 1–2+ mostly local | 1–2+ local |
| Lung, 3 | 1–2+ mostly local | 1–2+ local |
| Lymph node, 1 | 1+, diffuse and some endogenous peroxidase | Endogenous peroxidase |
| Lymph node, 2 | 1+ diffuse | Endogenous peroxidase |
| Lymph node, 3 | 1+ diffuse | Endogenous peroxidase |
| Ovary, 1 | 0 | 0 |
| Ovary, 2 | 0 | 0 |
| Ovary, 3 | 0 | 0 |
| Pancreas, 1 | Local 1–2+ in mucin | Local 1–2+ in mucin |
| Pancreas, 2 | Local 1–2+ in mucin | Local 1–2+ in mucin |
| Pancreas, 3 | Local 1–2+ in mucin | Local 1–2+ in mucin |
| Placenta, 1 | 2–3+ local staining | Endogenous peroxidase |
| Placenta, 2 | 2–3+ local staining | Some local endogenous peroxidase |
| Placenta, 3 | 2–3+ local staining | Some local endogenous peroxidase |
| Prostate, 1 | 0 | 0 |
| Prostate, 2 | 0 | 0 |
| Prostate, 3 | 0 | 0 |
| Skin, 1 | 0 | 0 |
| Skin, 2 | 0 | 0 |
| Skin, 3 | 0 | 0 |
| Spinal cord, 1 | 0 | 0 |
| Spinal cord, 2 | 0 | 0 |
| Spinal cord, 3 | 0 | 0 |
| Spleen, 1 | 1–2+ in red pulp | Endogenous peroxidase |
| Spleen, 2 | 1+ in red pulp | Endogenous peroxidase and some 1+ diffuse |
| Spleen, 3 | 1+ in red pulp | Endogenous peroxidase and some 1+ diffuse |
| Striated muscle, 1 | 0 | 0 |
| Striated muscle, 2 | 0 | 0 |
| Striated muscle, 3 | 0 | 0 |
| Stomach, 1 | 0 | Some endogenous peroxidase |
| Stomach, 2 | 2+, in mucin | 2+, in mucin |
| Stomach, 3 | 2+, in mucin | 2+, in mucin |
| Testis, 1 | 0 | Some local endogenous peroxidase |
| Testis, 2 | 0 | Some local endogenous peroxidase |
| Testis, 3 | 0 | Some local endogenous peroxidase |
| Thymus, 1 | 0 | 0 |
| Thymus, 2 | 0 | 0 |
| Thymus, 3 | 0 | 0 |
| Thyroid, 1 | 0 | 0 |
| Thyroid, 2 | 0 | 0 |
| Thyroid, 3 | 0 | 0 |
| Ureter, 1 | 0 | 0 |
| Ureter, 2 | 0 | Some local endogenous peroxidase |
| Ureter, 3 | 0 | Some local endogenous peroxidase |
| Uterus, endometrium, 1 | 0 | 0 |
| Uterus, endometrium, 2 | 0 | 0 |
| Uterus, endometrium, 3 | 2–3+ local in mucin | 2–3+ local in mucin |
| Uterus, cervix, 1 | 0 | 0 |
| Uterus, cervix, 2 | 0 | 0 |
| Uterus, cervix, 3 | 2–3+ local in mucin | 2–3+ local in mucin |
The staining intensity was determined as negative (0), weak staining (1+), moderate staining (2+), or strong staining (3+).