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. 2015 Sep;138:32–41. doi: 10.1016/j.exer.2015.06.007

Fig. 3.

Fig. 3

The Photoreceptor connecting cilium. A modified sensory cilium, comprising the axoneme, connecting cilium (CC) and basal bodies (BB), links the inner and outer segment in vertebrate photoreceptors. (a) Microtubule transport facilitates Rhodopsin Transport Carrier (RTC) delivery to the pericilliary membrane complex (green dotted line in (b), at the base of the BBs, prior to movement into the CC. The BBs co-ordinate microtubule assembly whilst the non-motile axoneme (comprising nine microtubule doublets) acts as a backbone and facilitates intra-flagellar transport (IFT) up and down the CC. (c) The CC serves to compartmentalise the photosensitive pigment rhodopsin into stacks of discs that fill the outer segment. The CC is therefore crucial for maintenance and survival of the photoreceptor. The diagram was modified from Maerker et al. (2008).