Table 1.
Characteristics of all enrolled patients and patients with measurable central venous oxygen saturation and strain
| Severe sepsis and septic shock, N =89 | Subset with measurable ScvO2 and strain, N =42 | |
|---|---|---|
| Females (%) | 48.3 | 52.4 |
| Age, yr | 57 (45, 65) | 57 (41, 66) |
| APACHE II score | 25 (20, 32) | 27 (21, 34) |
| Elixhauser comorbidity score | 5 (3, 6) | 5 (3, 6) |
| Source of sepsis (%) | ||
| Thoracic | 39.3 | 45.2 |
| Abdominal | 13.5 | 16.7 |
| Skin/soft tissue | 13.5 | 9.5 |
| Central nervous system | 1.1 | 2.4 |
| Urinary | 18.0 | 19.0 |
| Central venous catheter | 6.7 | 4.8 |
| Endocarditis | 1.1 | 0 |
| On mechanical ventilation (%) | 31.8 | 35.7 |
| Mean arterial pressure (mmHg) | 70 (65, 80) | 71 (65, 79) |
| Fluid administered before TTE (L) | 3.1 (1.2, 5.4) | 3.0 (1.0, 5.0) |
| Receiving vasopressor (%) | 39.3 % | 50.0 % |
| Norepinephrine-equivalent vasopressor dose among patients with shock (μg/kg/min) | 0.1 (0.05, 0.2) | 0.1 (0.05, 0.15) |
| With indwelling central venous catheter (%) | 60.7 % | 100 % |
| Central venous pressure (mmHg) | 11 (8, 14) | 11 (10, 14) |
| Longitudinal strain (%) | −15.3 (−18.9, −12.1) | −16.3 (−19.5, −12.3) |
| Ejection fraction (%) | 60.5 (44.2, 70.0) | 61.1 (44.0, 70.0) |
| Stroke volume (ml) | 61.2 (44.8, 77.3) | 60.6 (43.6, 76.4) |
| Cardiac output (L/min) | 6.2 (4.5, 7.9) | 6.1 (4.5, 7.4) |
| Hemoglobin (g/dl) | 10.9 (9.6, 12.7) | 11.4 (9.7, 12.9) |
| SpO2 (%) | 97 (94, 99) | 97 (95, 99) |
| ScvO2 (%) | 66 (57, 75) | 66 (57, 73) |
| Serum lactate (mmol/dl) | 2.1 (1.35, 3.3) | 2.1 (1.3, 3.3) |
APACHE II Acute Physiology and Chronic Health Evaluation II, ScvO 2 central venous oxygen saturation, SpO 2 peripheral capillary oxygen saturation, TTE transthoracic echocardiogram
Medians and interquartile ranges are reported for continuous data