Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Numerical simulation of the reversal of dabigatran therapy with exogenous prothrombin. Dabigatran concentration (250 nM) is the effective Cmax concentration at the pharmacokinetic 50th percentile. Three curves are illustrated; a “normal” thrombin generation curve with 1.4 μM prothrombin, the same numerical proteome mixture with Dabigatran added and the latter to which a 100% increase in prothrombin is included.
