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. 2015 Jul 31;94(30):e997. doi: 10.1097/MD.0000000000000997

FIGURE 4.

FIGURE 4

Correlation between histone acetylation and accumulation of DNA double-strand breaks in OLP. Each diamond shape represents 1 OLP patient. Increased acetylation of histone 3 correlates with accumulation of γH2AX. Note that OLP cases lacking histone acetylation (ac.H3 intensity “0”) have low levels of γH2AX (mean of 7.46). Patients with low levels of histone 3 acetylation (ac.H3 intensity “1”) have γH2AX expression in 18.78% of cells (P = 0.25). Patients with moderate and high expression of histone 3 acetylation are characterized by the accumulation of high levels of γH2AX (mean 40.72% and 38.98%, respectively) compared to OLP patients lacking histone 3 acetylation (∗∗∗P < 0.001). OLP = oral lichen planus.