Table 1.
Serine hydrolase signature associated with pancreatic cancer cell lines
| Gene* | Total cell lysate | Media | Cell surface | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean MS2# | P † | Mean MS2# | P † | Mean MS2# | P† | |||||||
| Pancreatic cancer | Other cancers | Fold change | Pancreatic cancer | Other cancers | Fold change | Pancreatic cancer | Other cancers | Fold change | ||||
| CES2 | 10.3 | 1.4 | 7.2 | <.001 | 12.7 | 0.7 | 17.2 | <.001 | 6.4 | 0.1 | 57.9 | <.001 |
| DPP4 | 11.2 | 1.4 | 8.2 | .02 | 34.7 | 9.7 | 3.6 | .04 | 39.6 | 34.8 | 1.1 | .16 |
| LIPA | 9.0 | 1.3 | 6.9 | <.001 | 32.7 | 17.6 | 1.9 | .006 | 3.7 | 0.2 | 17.3 | <.001 |
| ACOT1 | 2.3 | 1.0 | 2.3 | .79 | 0.0 | 0.0 | - | - | 3.4 | 0.3 | 11.6 | .001 |
| KLK6 | 7.1 | 0.9 | 8.3 | <.001 | 209.1 | 46.0 | 4.6 | .14 | 8.3 | 1.2 | 6.8 | .004 |
| KLK10 | 2.7 | 0.1 | 19.0 | <.001 | 79.8 | 4.9 | 16.4 | <.001 | 8.9 | 1.0 | 8.9 | <.001 |
| KLK11 | 1.0 | 0.0 | - | - | 20.6 | 2.5 | 8.1 | <.001 | 3.1 | 0.0 | 100.6 | .002 |
| TMPRSS4 | 0.4 | 0.1 | 3.3 | .007 | 4.9 | 0.0 | 183.6 | <.001 | 16.9 | 2.1 | 8.1 | .006 |
* Mean MS2 counts (MS2#) for eight serine hydrolases with statistically significantly elevated protein expression in pancreatic cancer cell lines compared with other cancer type cell lines.
† P values were calculated by two-sided Mann-Whitney t test.