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. 2015 May 9;107(8):djv123. doi: 10.1093/jnci/djv123

Figure 2.

Figure 2.

Effect of PF-04554878, a novel inhibitor of focal adhesion kinase (FAK) kinase activity, on growth of human pancreatic neuroendocrine tumor (PanNET) cells. A) Dose-response effect of PF-04554878 on colony formation of BON, QGP-1, and CM cells at low cell density after two- to four-week treatment as determined by the clonogenicity assay, and quantification of colonies for BON, QGP-1, and CM cells as determined by mechanical tally counter. Percent clonogenicity was calculated by normalizing colony counts to DMSO control. Error bars represent standard deviation of the mean. B) Viability of BON, QGP-1, and CM cells treated for 72 hours with increasing doses of PF-04554878 as determined by MTT assay. Percent viability was calculated by normalizing absorbance to DMSO control. Error bars represent standard deviation of the mean. C) Proliferation growth curves of BON, QGP-1, and CM cells treated for five days with DMSO control or PF-04554878 at GI25 or GI50 concentrations. Error bars represent standard deviation of the mean. GI50 = 50% growth inhibition, GI25 = 25% growth inhibition.