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. 2015 May 9;107(8):djv123. doi: 10.1093/jnci/djv123

Figure 6.

Figure 6.

Effect of dual targeting of focal adhesion kinase (FAK) and mTOR on pancreatic neuroendocrine tumor (PanNET) cell growth. A) Effect of PF-0455878 and everolimus alone and in combination using the fixed molar ratio method in QGP1 and CM cells. PF-0455878 and everolimus were combined in a constant EC50 ratio, followed by serial one-half dilutions of this combination. B) CalcuSyn graph of combination index values (CI) and fraction of cells affected (Fa) from fixed molar ratio combination of PF-04554878 and everolimus in QGP-1 and CM cells. C) Effect of everolimus alone and in combination with a single dose of PF-04554878 using the varying molar ratio method in QGP1 and CM cells. A single nonapoptogenic dose of PF-04554878 was combined with increasing concentrations of everolimus. D) CalcuSyn graph of combination index values (CI) and fraction of cells affected (Fa) from varying molar ratio combination of PF-04554878 and everolimus in QGP-1 and CM cells.