Table 1.
Participant Characteristics by MRSA Type at Time of Study Enrollment
| Characteristic | SCCmec II | SCCmec IV | P Value | SCCmec IV | SCCmec IV | P Value | |
|---|---|---|---|---|---|---|---|
| N = 199 | N = 88 | PVL(+)N = 50 | PVL(−)N = 38 | ||||
| Female | n (%) | 102 (51.3%) | 37 (42.1%) | 0.16 | 21 (42.0%) | 16 (42.1%) | 1.0 |
| Age in years | Mean (SD) | 11.5 (4.6) | 10.3 (5.0) | 0.40 | 10.0 (5.2) | 10.7 (4.6) | 0.41 |
| Age group | n (%) | ||||||
| <6 years | 31 (15.6%) | 16 (18.2%) | 0.03* | 11 (22.0%) | 5 (13.2%) | 0.63a | |
| 6–11 years | 65 (32.7%) | 41 (46.6%) | 22 (44.0%) | 19 (50.0%) | |||
| ≥12 years | 103 (51.8%) | 31 (35.2%) | 17 (34.0%) | 14 (36.8%) | |||
| CFTR genotype | n (%) | ||||||
| F508 del homozygous | 113 (56.8%) | 43 (48.9%) | 0.52* | 27 (54.0%) | 16 (42.1%) | 0.39a | |
| F508 del heterozygous | 71 (35.7%) | 36 (40.9%) | 18 (36.0%) | 18 (47.4%) | |||
| Other | 10 (5.0%) | 7 (8.0%) | 3 (6.0%) | 4 (10.5%) | |||
| Not done/missing | 5 (2.5%) | 2 (2.3%) | 2 (4.0%) | 0 (0%) | |||
| Pseudomonas aeruginosa | n (%) | 60 (30.2%) | 17 (19.3%) | 0.056 | 12 (24.0%) | 5 (13.2%) | 0.20 |
| BMI or Wt/length Percentile† | n: mean (SD) | 176: 44.3 (27.3) | 79: 46.4 (29.8) | 0.34 | 44: 41.2 (30.1) | 35: 53.0 (28.5) | 0.75 |
| FEV1% predicted‡ | n: mean (SD) | 141: 81.9 (22.0) | 64: 81.7 (22.5) | 0.82 | 34: 77.9 (22.7) | 30: 85.9 (21.9) | 0.16 |
Abbreviations: BMI, body mass index; CFTR, cystic fibrosis transmembrane regulator; FEV1, forced expiratory flow in 1 second; MRSA, methicillin-resistant Staphylococcus aureus; PVL, Panton-Valentine-leukocidin; SCCmec, staphylococcal cassette chromosome mec; SD, standard deviation; Wt/length, weight for length.
*P value for Fisher's test of distributional differences between groups.
†For children <2 years of age, weight for length is used in place of BMI.
‡FEV1% predicted is recorded only in participants >6 years of age (see Methods).