Table 2.

Discriminatory accuracy of each kallikrein model*

Model	Plasma AUC (95% CI)	Increment over “Age + total PSA” (P value)
Any-grade prostate cancer
Age + total PSA	0.634 (0.617 to 0.651)
Age + total PSA and free-to-total PSA ratio	0.710 (0.695 to 0.725)	0.076 (P < .001)
Age + panel of four kallikrein markers	0.719 (0.704 to 0.734)	0.085 (P < .001)
High-grade prostate cancer
Age + total PSA	0.738 (0.716 to 0.761)
Age + total PSA and free-to-total PSA ratio	0.799 (0.779 to 0.819)	0.060 (P < .001)
Age + panel of four kallikrein markers	0.820 (0.802 to 0.838)	0.082 (P < .001)

* This table outlines the three combinations of markers for predicting any-grade or Gleason score 7 or higher (high-grade) cancer at 10-core prostate biopsy based on kallikrein marker measurements in anticoagulated plasma provided by 4765 biopsied ProtecT participants. Areas under the curve were compared with models based on standard clinically available predictors using the DeLong test (26). All statistical tests were two-sided. CI = confidence interval; PSA = prostate-specific antigen.