Skip to main content
. 2015 Aug 3;7(33):18707–18716. doi: 10.1021/acsami.5b05228

Figure 1.

Figure 1

(A) Schematic procedures of our approach to PEGylated DNA–GNP drug nanocarriers. Thiolated PR-DNA (denoted as M1) was first loaded onto a citrate-stabilized 14 nm GNP via gold–thiol self-assembly to form GNP–M1, which was then hybridized to complementary MC2 (unmodified, route 1) or PEG-modified MC2s (route 2) to form the GNP–M1/MC2(PEG) carriers. (B) Schematic of MC2(EG12)3 preparation via the Michael addition between the maleimide-modified three-chain oligo(ethylene glycol) and the MC2-free sulfhydryl group, forming a stable covalently linked MC2(EG12)3.