Figure 3.

Schematic presentations of the YO-PRO-1 loaded (A) dsDNA and (B) PEGylated dsDNA–GNP systems under treatment of DNase I. The dsDNA only system is quickly degraded by DNase I, but the PEG-shield on the dsDNA–GNP can provide protection against DNase I digestion. (C) Normalized time-dependent fluorescence changes for the YO-PRO-1 loaded M1/MC2 and GNP–M1/MC2 (with or without PEGylation) conjugates after treatment with DNase I. (D) Comparison of initial rate of degradation velocities (%/min) over the first 30 min derived from C.