Table 3.
Multivariate analyses of overall survival
| OS | All patients | Fractionation 33 × 1.8 Gy | Fractionation 30 × 2.0 Gy | |||
|---|---|---|---|---|---|---|
| Factor | HR (95 % CI) | p-value | HR (95 % CI) | p-value | HR (95 % CI) | p-value |
| Interval surgery → RCT | 0.998 (0.987-1.009) | 0.705 | 0.985 (0.970-1.001) | 0.059 | 1.007 (0.994-1.020) | 0.312 |
| Age | 1.033 (1.020-1.045) | <0.001 | 1.031 (1.015-1.047) | <0.001 | 1.040 (1.019-1.061) | <0.001 |
| ECOG state > 1 | 0.984 (0.728-1.364) | 0.984 | 0.956 (0.638-1.431) | 0.522 | 0.974 (0.580-1.636) | 0.920 |
| RPA-class > 4 | 1.210 (0.905-1.617) | 0.199 | 1.240 (0.862-1.784) | 0.247 | 1.159 (0.702-1.912) | 0.564 |
| Incomplete resection | 1.886 (1.481-2.402) | <0.001 | 1.588 (1.152-2.189) | 0.005 | 2.265 (1.533-3.347) | <0.001 |
| Simultaneous CT | 0.573 (0.427-0.767) | <0.001 | 0.592 (0.419-0.837) | 0.003 | 0.535 (0.308-0.929) | 0.026 |
| Fractionation | 1.061 (0.807-1.396) | 0.672 | - | - | - | - |
| Radiation treatment time | 1.025 (0.985-1.068) | 0.225 | 1.013 (0.960-1.070) | 0.634 | 1.029 (0.964-1.098) | 0.394 |
| Age | 1.034 (1.021-1.047) | <0.001 | 1.031 (1.015-1.047) | <0.001 | 1.040 (1.019-1.061) | <0.001 |
| ECOG state > 1 | 1.006 (0.739-1.371) | 0.968 | 1.027 (0.692-1.525) | 0.893 | 0.947 (0.565-1.586) | 0.835 |
| RPA-class > 4 | 1.222 (0.914-1.634) | 0.175 | 1.244 (0.692-1.790) | 0.239 | 1.157 (0.700-1.913) | 0.570 |
| Incomplete resection | 1.927 (1.510-2.460) | <0.001 | 1.642 (1.183-2.278) | 0.003 | 2.301 (1.558-3.399) | <0.001 |
| Simultaneous CT | 0.584 (0.437-0.782) | <0.001 | 0.570 (0.405-1.801) | 0.001 | 0.581 (0.335-1.009) | 0.054 |
| Fractionation | 1.175 (0.865-1.595) | 0.302 | - | - | - | - |
| Overall duration of treatment | 1.000 (0.989-1.010) | 0.939 | 0.987 (0.971-1.002) | 0.084 | 1.008 (0.995-1.021) | 0.239 |
| Age | 1.033 (1.020-1.045) | <0.001 | 1.030 (1.014-1.046) | <0.001 | 1.040 (1.019-1.061) | <0.001 |
| ECOG state > 1 | 1.005 (0.735-1.375) | 0.974 | 0.858 (0.644-1.443) | 0.858 | 0.976 (0.581-1.640) | 0.928 |
| RPA-class > 4 | 1.209 (0.905-1.616) | 0.199 | 1.231 (0.855-1.773) | 0.263 | 1.169 (0.708-1.931) | 0.542 |
| Incomplete resection | 1.884 (1.479-2.399) | <0.001 | 1.571 (1.139-2.166) | 0.006 | 2.256 (1.527-3.333) | <0.001 |
| Simultaneous CT | 0.568 (0.424-0.759) | <0.001 | 0.582 (0.413-0.821) | 0.002 | 0.535 (0.308-0.928) | 0.026 |
| Fractionation | 1.068 (0.805-1.418) | 0.648 | - | - | - | - |
The impact of time interval from surgery until initiation of radio- or radiochemotherapy (RCT), radiation treatment time and overall duration of local treatment from surgery to the end of radio- or radiochemotherapy on overall survival (OS) is shown