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. Author manuscript; available in PMC: 2015 Nov 13.
Published in final edited form as: J Am Chem Soc. 2015 Apr 30;137(18):6067–6077. doi: 10.1021/jacs.5b02510

Table 3.

Comparison of His37 pKa’s in different M2 constructs bound to varying membranes.

M2 Phospholipid membranes pKa’s Average pKa
M2(21–97) POPC, POPE, SM, cholesterol 7.1, 5.4 6.3
M2(18–60) 28 DPhPC 7.6, 4.5 6.1
M2(22–46) 17 DPPC, DPPE, SM, cholesterol 7.6, 6.8, 4.9, 4.2 5.9
M2(22–46) 19 DMPC, DMPG 8.2, 8.2, 6.3, < 5.0 < 6.9