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. 2015 Jul 31;21:2218–2224. doi: 10.12659/MSM.893514

Figure 4.

Figure 4

β-catenin inactivation inhibits cell proliferation and induces apoptosis in Jeko-1 cells. (A) Jeko-1 cells were treated with 0, 2, or 8 μmol/L XAV939 were tested for cell proliferation by MTT assay. XAV939 treatment reduced the viability of Jeko-1 cells in a dose-dependent manner (P<0.01 by two-way ANOVA; n=3). Data presented as mean ±SEM; (B) Quantification of apoptotic cell percentage by flow cytometry. XAV939 treated Jeko-1 cells composed of a larger subset of apoptotic cells compared to control cells (P<0.01 by t test; n=3) (C) XAV939 treatment decreased β-catenin, c-Myc, Cyclin D1, and Bcl-2 protein levels, and increased caspase-3 and Bax expression in Jeko-1 cells.