Table 2.
Reproductive performance in BRCA mutation carriers
| Author | Numbera | Patients diagnosis | Endpoint | Results |
|---|---|---|---|---|
| Comparable/superior reproductive performance in BRCA mutation carriers | ||||
| Pal et al. [41] | 2245 | Breast cancer, non-cancer | Parity Infertility Age at first birth |
NS NS NS |
| Smith et al. [42] | 181 | Non-cancer | Parity | p = 0.01 |
| Finch et al. [43] | 908 | Non-cancer | Parity Use of infertility drugs Fertility problems |
NS NS NS |
| Collins et al. [44] | 829 | Non-cancer | Age at menopause | NS |
| Valentini et al. [45] | 1426 | Breast cancer | Risk for amenorrhea post chemotherapy | NS |
| Michelson-cohen et al. [46] | 43 | Non-cancer | AMH Levels | NS |
| Van Tilborg et al. [47] | 1236 | Breast cancer, non-cancer | Age at menopause | NS |
| Verpoest et al. [48] | 13 | Non-cancer | IVF performance | NS |
| Diminished reproductive performance in BRCA mutation carriers | ||||
| Rzepka-Górska et al. [49] | 39 | Breast cancer | Age at menopause | p < 0.05 |
| Oktay et al. [50] | 12 | Breast cancer | IVF performance | p = 0.001 |
| Lin et al. [51] | 382 | Non-cancer | Age at menopause | P = 0.01 |
| Finch et al. [43] | 908 | Non-cancer | Age at menopause | p = 0.001 |
| Titus et al. [52] | 24 | Breast cancer | AMH levels | p < 0.0001 |
| Wang et al. [53] | 143 | Non-cancer | AMH levels | P < 0.012 |
aNumber of BRCA1/2 mutation carriers included in study