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. 2015 Aug 24;10:5263–5271. doi: 10.2147/IJN.S88363

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© 2015 Kim et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The relative fluorescence intensity profiles of DiR-loaded cationic NPs (■) or free DiR solution (□) after IA injection in mice knee.

Notes: The relative fluorescence intensities were expressed as fold-changes versus those determined immediately after IA injection (day 0) (n=3). The statistical analysis was performed using the Student’s t-test; *P<0.05 versus probe solution; **P<0.01 versus probe solution.

Abbreviations: DiR, 1,1′-dioctadecyl-3,3,3′,3′ tetramethylindotricarbocyanine iodide; NP, nanoparticle; IA, intra-articular; PLGA, poly(lactide-co-glycolide).