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. 2015 Aug 24;10:5273–5292. doi: 10.2147/IJN.S88052

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© 2015 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The in vitro intercalation of PZL318 towards CT DNA.

Notes: (A) Hypochromic effect and bathochromic shift occurred in the UV spectra of PZL318 plus CT DNA (0 μM, 6.0 μM, 12.0 μM, 18.0 μM, 24.0 μM, and 30.0 μM). (B) Course of fluorescence quenching of PZL318. In PBS (pH 7.4) the titration of 20 μL of CT DNA (0 μM, 6.0 μM, 12.0 μM, 18.0 μM, 24.0 μM, 30.0 μM, and 36.0 μM) concentrations dependently resulted in the typical course of fluorescence quenching of PZL318. (C) Effect of PZL318 on the CD spectra of CT DNA. A consistent variation of the intensity of both positive and negative bands in the CD spectra of CT DNA resulted from the intercalation of PZL318 toward CT DNA. (D) Effect of PZL318 at various concentrations on the relative viscosity of CT DNA (5.0×10⁻⁴ M; 28°C).

Abbreviations: CT DNA, calf thymus DNA; UV, ultraviolet; PBS, phosphate buffered saline; CD, circular dichroic.