Figure 4.
Efficacies of human-simulated regimens of 500 mg of DOR given every 8 hours and 2 g of DOR given every 8 hours as a 4-hour infusion (A) and 1 g of ETP given every 24 hours (B) in a neutropenic murine thigh infection model.
Note: *Denote a statistically higher efficacy of the higher DOR dose as compared to the lower DOR dose. Reproduced with permission from the American Society for Microbiology. Copyright © American Society for Microbiology. Wiskirchen DE, Nordmann P, Crandon JL, Nicolau DP. In vivo efficacy of human simulated regimens of carbapenems and comparator agents against NDM-1-producing Enterobacteriaceae. Antimicrob Agents Chemother. 2014;58(3):1671–1677.50
Abbreviations: CFU, colony-forming units; DOR, doripenem; EC, Escherichia coli; ETP, ertapenem; KP, Klebsiella pneumoniae.