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. 2015 Aug 24;8:297–309. doi: 10.2147/IDR.S39186

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© 2015 Zmarlicka et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Comparative efficacy of a human-simulated dose of 2,000 mg aztreonam q6h (1-hour infusion) as monotherapy or combined with 375 mg avibactam q6h (ATM-AVI 375 mg) or 600 mg avibactam q6h (ATM-AVI 600 mg) against Enterobacteriaceae in a neutropenic-mouse thigh infection.

Note: Reproduced with permission from the American Society for Microbiology. Copyright © American Society for Microbiology. Crandon JL, Nicolau DP. Human simulated studies of aztreonam and aztreonam-avibactam to evaluate activity against challenging gram-negative organisms, including metallo-beta-lactamase producers. Antimicrob Agents Chemother. 2013;57(7):3299–3306.⁵¹

Abbreviations: ATM, aztreonam; AVI, avibactam; CFU, colony-forming units; EC, Escherichia coli; KP, Klebsiella pneumoniae.