Fig. 4.

3xTg mice show no impairment in learning or memory during testing in the MWM at 10 or 20 months of age a 1 month data reflects that all groups learned the MWM to criterion (latency to platform < 20 s) (repeated measures ANOVA F(3,198) = 1.97, p = 0.16) and b all groups at the 1 month timepoint, remembered the location of the platform 24 h after their last training session (Con F(3,27) = 13.44, Flu F(3,27) = 54.91, Run F(3,24) = 11.60, FluxRun F(3,27) = 17.09, P < 0.001) Bonferroni post test p < 0.05 target versus each quandrant c 10 months after starting the experiment, 3xTg mice were re-trained and Con, Run, and FluxRun showed significant preferences for the target quadrant during 4 h probe trials (Con F(3,12) = 9.00, Run F(3,21) = 6.00, FluxRun F(3,18) = 9.34, P < 0.01) Bonferroni post-test p < 0.05 target versus each quandrant, Flu F(3,21) = 2.94, p = 0.06) d 24 h probe trials (Con F(3,12) = 13.14, Run F(3,21) = 21.50, FluxRun F(3,18) = 22.81, P < 0.01) Bonferroni post-test p < 0.05 target versus each quadrant. Flu did not show a significant preference for the target quadrant