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Mechanism of action of XN in pancreatic cancer cell lines. A. Levels of cleaved PARP, and cleaved caspase-3 (markers of apoptosis) were analyzed from lysates after 48hrs of XN treatment by Western. A level of anti-apoptotic protein survivin was also determined. GAPDH was used as loading control. B. Caspase-3 and -7 activities were measured by caspase-Glo3/7 assay. (n=3; * p<0.05 compared to control in all cell lines tested, NS, not significant).
