Figure 1. Patterns of gene expression in NZB/W mice.

A. Numbers of regulated genes (number of human orthologs) between the indicated stages of disease progression. Dominant pathologic processes identified by IPA are shown for each disease stage. B. Numbers of regulated genes between the indicated stages before (black) and after (green) remission induction. The Venn-diagram shows the 654 genes regulated in both during proteinuria onset and remission. NP: non-proteinuric; P: proteinuric. C. Self-organizing map of datasets from each of the indicated disease stages. Number of dots in each module reflects the number of regulated genes and the color reflects the degree of change - either up (red – Cluster 1) or down (white – Cluster 2) or not changing (blue). D. Average gene expression for each data set in three representative modules.