Table 2.

Variants which were associated with lung cancer and first degree family history of lung cancer and were validated in Stage 2

			Ref. effect allele	Position (NCBI Build 36)	Meta-analysis (Discovery)					Meta-analysis (Replication)		Combined-analysis (overall)
Chr	Gene	SNP			OR (FH)	P value (FH)	OR (LC)	P value (LC)	BFDP (LC)	OR (LC)	P value (LC)	OR (LC)	p-value (LC)
1	FAM5C	rs6678713	A,G	188,656,364	1.17	0.0236	1.08	0.0270	0.7180	1.06	0.0360	1.06	0.0026
2	ALLC	rs6542651	T,C	3,737,705	1.26	0.0443	1.17	0.0070	0.7913	1.10	0.0219	1.13	0.0006
2	DPP10	rs9308697	T,C	115,124,129	1.19	0.0254	1.09	0.0191	0.6270	1.08	0.0072	1.08	0.0006
4	KCNIP4	rs1158970	C,T	20475567	0.78	0.0136	0.90	0.0130	0.9657	0.89	0.0002	0.89	9.64E-06
4	FRAS1	rs1546318	T,G	79,168,396	1.25	0.0283	1.16	0.0053	0.2854	1.11	0.0187	1.13	0.0003
4	FRAS1	rs1393644	A,C	791,757,31	1.25	0.0310	1.15	0.0072	0.3474	1.09	0.0190	1.11	0.0008
6	ATXN1	rs17669356	T,C	16,801,065	0.80	0.0154	0.92	0.0344	0.7315	0.94	0.0377	0.93	0.0033
6	C6orf205	rs2844680	G,T	31054475	1.16	0.0294	1.10	0.0498	0.5168	1.07	0.0055	1.07	0.0009
6	PKIB	rs7452823	T,C	123,047,594	0.87	0.0484	0.94	0.0486	0.8028	0.93	0.0031	0.94	0.0007
7	TSPAN13	rs2389700	C,T	16,788,162	1.27	0.0066	1.11	0.0164	0.5756	1.08	0.0398	1.09	0.0019
7	MTERF	rs2157998	T,C	91158790	0.84	0.0187	0.93	0.0343	0.9834	0.95	0.0499	0.95	0.0062
8	ZFPM2	rs285823	T,C	106,171,356	1.17	0.0264	1.09	0.0128	0.5605	1.07	0.0102	1.08	0.0002
8	ADCY8	rs7017572	G,A	132,398,482	1.14	0.0438	1.07	0.0416	0.5655	1.07	0.0191	1.07	0.0019
9	PTPRD	rs10959312	C,T	10,802,417	0.80	0.0116	0.89	0.0043	0.9330	0.94	0.0343	0.92	0.0004
9	DBH	rs2007153	C,T	135,493,640	0.87	0.0499	0.92	0.0175	0.9258	0.95	0.0280	0.94	0.0012
10	CACNB2	rs7901587	C,T	18,447,963	1.27	0.0071	1.10	0.0432	0.9932	1.08	0.0252	1.09	0.0026
10	FFAR4	rs12415204	C,A	95,320,880	1.18	0.0255	1.14	0.0004	0.0471	1.06	0.0414	1.09	0.0002
10	SORCS1	rs10509832	C,T	109,070,424	1.15	0.0426	1.07	0.0454	0.7953	1.08	0.0056	1.07	0.0007
11	FAM76B	rs10831422	T,C	95,118,616	0.85	0.0269	0.92	0.0189	0.9577	0.94	0.0174	0.93	0.0010
11	FAM76B	rs11021302	G,A	95,125,416	0.84	0.0153	0.93	0.0227	0.9812	0.94	0.0086	0.94	0.0013
11	SORL1	rs1503415	A,C	120,991,762	1.16	0.0368	1.07	0.0468	0.7932	1.06	0.0337	1.07	0.0037
13	PCDH17	rs7991911	G,A	58,036,178	1.25	0.0422	1.12	0.0497	0.7101	1.11	0.0085	1.12	0.0010
15	CYP19A1	rs10519295	T,C	49,319,939	0.79	0.0463	0.89	0.0402	0.9445	0.90	0.0124	0.91	0.0028
17	VAMP2	rs2278637	T,G	8,002,827	0.85	0.0257	0.93	0.0486	0.5776	0.94	0.0214	0.94	0.0025
18	DYM	rs833520	C,T	44,818,557	1.24	0.0053	1.08	0.0395	0.9954	1.08	0.0211	1.08	0.0020
18	DYM	rs10520770	T,C	44,856,962	0.86	0.0228	0.92	0.0072	0.4606	0.95	0.0283	0.94	0.0012
18	DYM	rs2078286	G,A	45,132,860	0.85	0.0190	0.93	0.0317	0.9826	0.93	0.0107	0.93	0.0009
18	CBLN2	rs1443321	G,A	68,035,323	1.24	0.0183	1.1	0.0438	0.9819	1.08	0.0383	1.09	0.0040
19	ZNF537	rs2032868	T,C	36,692,866	0.83	0.0065	0.90	0.0300	0.6794	0.94	0.0216	0.93	0.0022
21	C21orf34	rs1014602	G,T	17,263,238	1.16	0.0483	1.14	0.0228	0.9088	1.07	0.0196	1.08	0.0014