Table 3.
Patient Characteristics and Univariable Analyses of Postrecurrence Survival
| Characteristic | No. (%) | Median PRS (95% CI), Months | P* |
|---|---|---|---|
| Total No. of patients | 188 | 26.1 (20.4 to 36.3) | |
| Primary tumor factor | |||
| Age at surgery, years | |||
| ≤ 65 | 73 (39) | 37.1 (22.6 to 62.5) | .003 |
| > 65 | 115 (61) | 21.2 (16.1 to 28.7) | |
| Sex | |||
| Female | 104 (55) | 23.4 (17.3 to 38.2) | .66 |
| Male | 84 (45) | 26.3 (21.2 to 38.1) | |
| Smoking history | |||
| Never | 28 (15) | 46.5 (27.4 to NA) | .037 |
| Ever | 160 (85) | 23.4 (17.5 to 32.8) | |
| Surgical procedure† | |||
| Lobectomy | 113 (60) | 29.5 (21.1 to 42.1) | .043 |
| Sublobar resection | 75 (40) | 20.7 (14.8 to 34.3) | |
| T factor | |||
| T1a | 83 (44) | 27.5 (19.0 to 45.5) | .61 |
| T1b | 33 (18) | 30.8 (22.9 to 45.7) | |
| T2a | 72 (38) | 17.4 (13.2 to 38.1) | |
| Pathologic stage | |||
| IA | 116 (62) | 27.5 (22.9 to 38.2) | .62 |
| IB | 72 (38) | 17.4 (13.2 to 38.1) | |
| Predominant histologic subtype | |||
| Lepidic | 8 (4) | NA | < .001 |
| Acinar | 69 (37) | 27.6 (22.6 to 39.1) | |
| Papillary | 35 (19) | 38.1 (28.7 to NA) | |
| Micropapillary | 26 (14) | 43.8 (17.6 to NA) | |
| Solid | 40 (21) | 8.7 (4.7 to 15.3) | |
| Invasive mucinous | 8 (4) | NA | |
| Colloid | 2 (1) | NA | |
| Architectural grade | |||
| Low and intermediate | 112 (60) | 35.0 (25.5 to 40.1) | .012 |
| High | 76 (40) | 16.1 (11.8 to 27.4) | |
| Solid predominant | |||
| No | 148 (79) | 30.1 (25.5 to 41.9) | < .001 |
| Yes | 40 (21) | 8.7 (4.7 to 15.3) | |
| Micropapillary predominant | |||
| No | 162 (86) | 26.1 (18.9 to 36.2) | .68 |
| Yes | 26 (14) | 43.8 (17.6 to N/A) | |
| Lymphatic invasion | |||
| Absent | 80 (43) | 28.7 (16.3 to 45.5) | .96 |
| Present | 108 (57) | 26.1 (20.4 to 36.3) | |
| Vascular invasion | |||
| Absent | 107 (57) | 36.5 (25.5 to 45.7) | .019 |
| Present | 81 (43) | 17.4 (14.8 to 31.6) | |
| Pleural invasion | |||
| Absent | 144 (77) | 27.5 (20.7 to 37.4) | .53 |
| Present | 44 (23) | 17.2 (10.1 to 41.9) | |
| Postrecurrence factor | |||
| Age at recurrence, years | |||
| ≤ 65 | 53 (28) | 45.7 (20.4 to NA) | .007 |
| > 65 | 135 (72) | 23.4 (17.4 to 32.8) | |
| Recurrence pattern | |||
| Locoregional only | 59 (31) | 42.1 (31.6 to 60.3) | .007 |
| Distant | 129 (69) | 17.6 (15.2 to 27.4) | |
| Recurrence site | |||
| Single site | 131 (70) | 35.0 (26.2 to 43.8) | .001 |
| Multiple site | 57 (30) | 11.4 (6.2 to 17.5) | |
| Intrathoracic | 102 (54) | 41.9 (32.8 to 55.0) | < .001 |
| Extrathoracic | 86 (46) | 12.0 (9.8 to 17.5) | |
| Recurrence-free interval, months | |||
| ≤ 24 | 105 (56) | 17.2 (14.0 to 26.2) | .034 |
| > 24 | 83 (44) | 37.4 (31.6 to 48.3) |
Abbreviations: NA, not applicable; PRS, postrecurrence survival.
*
Significant P values (< .05) are shown in bold type.
†
Lobectomy: pneumonectomy, bilobectomy, or lobectomy; sublobar resection: segmentectomy or wedge resection.