Table 4.

Multivariable Analysis in Predicting Postrecurrence Survival

Factor	HR	95% CI	P*
Primary tumor factors
Age at diagnosis (> 65 v ≤ 65 years)	1.63	1.12 to 2.37	.01
Smoking (ever v never)	1.64	0.94 to 2.88	.083
Surgical procedure (sublobar resection v lobectomy)	1.6	1.12 to 2.29	.01
Vascular invasion (present v absent)	1.41	0.97 to 2.06	.073
Histologic pattern
High-grade v low- or intermediate-grade SOL	1.76	1.11 to 2.77	.016
High-grade v low- or intermediate-grade non-SOL†	1.2	0.75 to 1.91	.44
Postrecurrence factors
Age at recurrence (> 65 v ≤ 65 years)	1.7	1.12 to 2.6	.014
Recurrence-free interval (≤ 24 v > 24 months)	1.22	0.84 to 1.77	.31
Recurrence pattern (multiple-site v single-site)	1.5	0.99 to 2.28	.058
Distant, intrathoracic v locoregional	0.88	0.51 to 1.49	.62
Distant, extrathoracic v locoregional	1.76	1.13 to 2.76	.013

Abbreviations: HR, hazard ratio; SOL, solid predominant.

^*Significant P values (< .05) are shown in bold type.

^†High-grade: SOL v non-SOL, P = .19.