Table 4.
Mutation Status by Age at Disease Onset and Histologic Subtype in Patient Cases With Ovarian Cancer
| Mutation Status | No. (%) of Patients by Age at Diagnosis, Years |
Histology, No. (%) |
|||||
|---|---|---|---|---|---|---|---|
| < 40 | 40-49 | 50-59 | ≥ 60 | Unknown | High-Grade Serous | Other | |
| Noncarrier (n = 3,401) | 165 (4.9) | 514 (15) | 1,073 (32) | 1,642 (48) | 7 (0.2) | 1,786 (53) | 1,615 (47) |
| Mutation carrier (n = 28) | 0 | 5 (18) | 11 (39) | 12 (43) | 0 | 20 (71) | 8 (29) |
| RAD51B (n = 2) | 0 | 0 | 0 | 2 (100) | 0 | 1 (50) | 1 (50) |
| RAD51C (n = 14) | 0 | 4 (29) | 5 (36) | 5 (36) | 0 | 10 (71) | 4 (29) |
| RAD51D (n = 12) | 0 | 1 (8.3) | 6 (50) | 5 (42) | 0 | 9 (75) | 3 (25) |