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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2015 May 27;86:90–101. doi: 10.1016/j.freeradbiomed.2015.05.028

Table 1. Microscopic findings in myocardia from control, SFN, DOX+/−SFN treated mice.

Cytoplasmic vacuolization Myofibrillar disruption Fibrosis
Control 0/4 0/4 0/4
SFN 0/4 0/4 0/4
DOX 8/8 (2.6) 8/8 (2.5) 3/8 (1)
DOX+SFN 2/8 (1) 3/8 (1) 0/8

Myocardial tissue was examined for cytoplasmic and myofibrillar changes and fibrosis. Data are presented as number of animals affected/number of animals examined; average severity (ranging from 1 to 3, least to most severe) of affected animals is indicated in parentheses. Microscopic examination was determined by a pathologist using scoring criteria described in the Materials and methods.