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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Jul 26;1848(10 0 0):2374–2384. doi: 10.1016/j.bbamem.2015.07.013

Fig. 3.

Fig. 3

The inhibitory potency of Bcl-xL mutants on ceramide channels formed in isolated mitochondria. The final concentration of added Bcl-xL or mutant proteins was 0.72 μM (A) and 2.1 μM (B). C. Relative inhibition of ceramide induced MOMP by Bcl-xL mutants. The inhibitory ability is expressed relative to that of the wild-type so that if it is the same as the wild type the result would be 1. As indicated in the text, this corrects both for variability from experiment to experiment and for the use of different concentrations of protein to reveal changes in inhibitory potency of both the weak and strong mutants. The statistically significant differences from the potency of the wild-type are indicated by the asterisk.