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. 2015 Aug 12;5(8):150082. doi: 10.1098/rsob.150082

Figure 3.

Figure 3.

Structural dissection of Plk4/ZYG-1. (a) Schematic showing domain organization of Plk4/ZYG-1. (b) Ribbon diagram of the crystal structure of the human Plk4 kinase domain loaded with an ATP analogue (PDB code: 3COK). The structure is colour-ramped from blue (N-terminus) to red (C-terminus). The bound nucleotide is shown as sticks. (c) (i) Ribbon diagram and (ii) corresponding electrostatic surface plot of the crystal structure of the Drosophila Plk4 CPB dimer (PDB code: 4NK7). (d) (i) Ribbon diagram and (ii) corresponding electrostatic surface plot of the crystal structure of the ZYG-1 CPB dimer (PDB code: 4NKB). (e) Crystal structure of human Plk4 CPB in complex with the acidic region of SPD-2 (dark blue) (PDB code: 4N7Z). (f) Crystal structure of human Plk4 CPB in complex with the acidic region of Asterless (pink) (PDB code: 4N7 V). (g) Ribbon diagram of the crystal structure of the mouse Plk4 PB3 (PDB code: 1MBY). Different molecules in all ribbon diagrams are coloured differently. Positive and negative charges in the electrostatic plots are shown in blue and red, respectively.